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Tamolarizine (Tamolarizine free base) free base 是一种新型的钙拮抗剂。
Tamolarizine (Tamolarizine free base) free base 是一种新型的钙拮抗剂。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,010 | 现货 | |
5 mg | ¥ 2,490 | 现货 | |
10 mg | ¥ 3,720 | 现货 | |
25 mg | ¥ 5,990 | 现货 | |
50 mg | ¥ 8,290 | 现货 | |
100 mg | ¥ 10,900 | 现货 | |
500 mg | ¥ 22,300 | 现货 |
产品描述 | Tamolarizine (Tamolarizine free base) free base is a novel calcium antagonist. |
体外活性 | Tamolarizine (0.1-10 microM) synergistically potentiated the cytotoxicity of doxorubicin for doxorubicin-resistant K562 cells (K562/DXR), but had hardly any synergistic effects in the parental cell line (K562) at the same concentration. Moreover, tamolarizine inhibits the P-glycoprotein pump-efflux activity in a dose-related manner and reduces the expression of the immunoreactive P-glycoprotein in K562/DXR cells as evaluated by cytofluorimetric assay.[1] |
体内活性 | Tamolarizine (40 mg/kg; rats; immediately after 15-min brain ischemia) showed slight impairment of place learning during the course of this test, they later reached almost the same performance level as the sham-operated group. Selective neuronal loss in the CA1 subfield was much less in the ischemia+tamolarizine group than in the ischemia+saline group. These results indicate that tamolarizine treatment protects the hippocampus from ischemic brain damage and ameliorates place learning impairment.[2] |
别名 | Tamolarizine, Tamolarizine HCl, Tamolarizine free base, NC 1100, NC1100, Tamolarizine dihyrchloride, 他莫利嗪, NC-1100 |
分子量 | 432.55 |
分子式 | C27H32N2O3 |
CAS No. | 93035-32-6 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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